Local Ca2+ signals couple activation of TRPV1 and ANO1 sensory ion channels.
Shah S, Carver CM, Mullen P, Milne S, Lukacs V, Shapiro MS, Gamper N. Sci Signal. 2020 Apr 28;13(629):eaaw7963.
Mechanically activated ion channel PIEZO1 is required for lymphatic valve formation.
Nonomura K, Lukacs V, Sweet DT, Goddard LM, Kanie A, Whitwam T, Ranade SS, Fujimori T, Kahn ML, Patapoutian A. Proc Natl Acad Sci U S A. 2018 Dec 11;115(50):12817-12822.
GPR68 Senses Flow and Is Essential for Vascular Physiology.
Xu J, Mathur J, Vessières E, Hammack S, Nonomura K, Favre J, Grimaud L, Petrus M, Francisco A, Li J, Lee V, Xiang FL, Mainquist JK, Cahalan SM, Orth AP, Walker JR, Ma S, Lukacs V, Bordone L, Bandell M, Laffitte B, Xu Y, Chien S, Henrion D, Patapoutian A. Cell. 2018 Apr 19;173(3):762-775.e16.
Ma S, Cahalan S, LaMonte G, Grubaugh ND, Zeng W, Murthy SE, Paytas E, Gamini R, Lukacs V, Whitwam T, Loud M, Lohia R, Berry L, Khan SM, Janse CJ, Bandell M, Schmedt C, Wengelnik K, Su AI, Honore E, Winzeler EA, Andersen KG, Patapoutian A. Cell. 2018 Apr 5;173(2):443-455.e12.
Piezo2 is the principal mechanotransduction channel for proprioception.
Woo SH, Lukacs V, de Nooij JC, Zaytseva D, Criddle CR, Francisco A, Jessell TM, Wilkinson KA, Patapoutian A. Nat Neurosci. 2015 Dec;18(12):1756-62. PMID: 26551544
Lukacs V, Mathur J, Mao R, Bayrak-Toydemir P, Procter M, Cahalan SM, Kim HJ, Bandell M, Longo N, Day RW, Stevenson DA, Patapoutian A, Krock BL. Nat Commun. 2015 Sep 21;6:8329. PMID: 26387913
Piezo1 links mechanical forces to red blood cell volume.
Cahalan SM, Lukacs V, Ranade SS, Chien S, Bandell M, Patapoutian A. Elife. 2015 May 22;4:e07370. PMID: 26001274
Lukacs Lab 